all about niacin
A “no-flush” niacin source
Niacinate provides inositol hexaniacinate, a safe and effective alternative to conventional niacin preparations. This compound, formed from niacin and inositol, a member of the B-vitamin family, eliminates the uncomfortable skin flushing and itching side effect of high dose niacin.
Studies show this compound supports the metabolism of fat and cholesterol as well as regular niacin.
Inositol Hexa-niacinate(a.k.a. IHN)
by Ron Kennedy, M.D., Santa Rosa, California
This nifty molecule is make of inositol, which lowers cholesterol all by itself, with six niacin molecules attached.
It has long been appreciated that niacin will lower cholesterol by accelerating its metabolism, but use of niacin has been limited by the “flush reaction.” About 30-60 minutes after any significant dose of niacin, the face turns beet red and becomes hot as a firecracker. This then spreads to the chest and abdomen. This reaction demonstrates niacin’s ability to dilate blood vessels, but makes taking it too uncomfortable for most people. It also limits dosages to the relatively non-therapeutic range.
With inositol hexa-niacinate, this flush is almost non-existent as the niacin is slowly released. This allows therapeutic doses of 2-4 grams per day to be easily reached. Liver enzyme studies should be done four weeks after therapy begins to be certain that large doses of niacin can be handled by the individual.
Good Source of Non – Flush Niacin
Posted on NaturalStrength.com on November 16, 2003
Inositol hexanicotinate consists of six molecules of niacin surrounding a molecule of inositol- an unofficial B vitamin. This inositol-bound form of niacin is slowly metabolized in the body and releases niacin over a period of time without the characteristic flush that may occur when large doses of niacin are administrated. It has been clinically tested as an effective cholesterol-lowering agent and is found to be slightly more effective than niacin to lower blood cholesterol levels. Inositol hexanicotinate has been used to lower cholesterol and also to improve blood flow in the treatment of intermittent claudication ( a painful cramp in calve muscles produced by a decreased oxygen supply to the muscles). Some studies show that compared to niacin, inositol hexanicotinate is safer and better tolerated. It is important to note that inositol hexanicotinate is not a timed-release form of niacin.